ATM deficiency confers specific therapeutic vulnerabilities in bladder cancer.

Sci Adv · 2023 · PMC10664985 · PMID 37992168

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In addition, BBN963-ATM-KO samples showed a trend toward increased T cell receptor (TCR) diversity, which has been associated with improved anti-PD1/PD-L1 responses in bladder cancer ( 27 ), as well as increased immune score and higher expression of granzyme B ( GZMB ) and other genes that have been associated with improved anti-PD1/PD-L1 response (fig.

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