Highly significant changes were identified by either a SIFT score of < 0.05 and/or a VEP “Putative Impact Score” of high (McLaren et al., 2016).
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Mice with FVB-derived sequence on chromosome 17 succumb to disseminated virus infection due to aberrant NK cell and T cell responses.
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NK-depleted mice showed a trend toward increased number of GrzB + T cells by 6 days of infection ( Figures S7 C and S7G).