Retroperitoneal Soft Tissue Sarcoma: Emerging Therapeutic Strategies.

In an analysis of subgroups according to grade, no difference in terms of occurrence of metastatic disease was observed for grade 1 and 2 tumours between the treatment periods, whereas a highly significant increase in the number of patients with metastases for grade 3 tumours was noted in the recent period ( p = 0.0002).

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In the Italian comparative study of standard versus more aggressive surgery [ 15 ], the addition of RT, administered preoperatively or postoperatively, seemed to result in LR reduction ( p = 0.023) and a strong trend towards increased OS ( p = 0.050).

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