Frequency Evaluation of the <i>Interleukin-6</i> -174G>C Polymorphism and <i>Homeostatic Iron Regulator (HFE)</i> Mutations as Disease Modifiers in Patients Affected by Systemic Lupus Erythematosus and Rheumatoid Arthritis.

Int J Mol Sci · 2023 · PMC10671518 · PMID 38003490

Europe PMC DOI

hedged sentences

0.0915

closest p · 1.8× alpha

0.0915

boldest claim

The sentences

a trend toward significancep = 0.0915so close (0.05 < p ≤ 0.1)

Conversely, the comparison with the Tuscan population only showed a trend toward significance (Allele dominant, OR, p = 0.0915; Chi-square, p = 0.874; Allele contrast, OR, p = 0.0938; Chi-square, p = 0.0929).

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a decreasing trendno p-value reported

The comparison with the Tuscan 1000 G population only showed a decreasing trend without reaching statistical significance.

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did not reach statistical significanceno p-value reported

The two mutations p.His63Asp and p.Ser65Cys in the HFE gene did not reach statistical significance in any of the comparisons, regardless of the statistical model, cohorts of patients and control populations analyzed.

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