The Association between Direct Oral Anticoagulants Prescribing Behavior and Non-Valvular Atrial Fibrillation Outcomes: An Instrumental Variable Analysis of Real-World Data

Primary Analyses In the unadjusted analysis, there was a 28% greater hazard of major bleeding associated with the highest preference for rivaroxaban (81–100%), relative to the lowest (0–20%) (HR 80-100 = 1.28; 95% CI: 0.89, 1.85, p trend = 0.079 [ Table 3 ]); however, this association did not reach statistical significance.

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