Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status.

7p ), BMC in the ΔATGL male mice showed a decreasing trend (Fig. 7q ) (decreased from 608.5 ± 16.16 mg to 580.8 ± 11.32 mg), and the BMD decreased from 74.04 ± 1.357 mg·cm −2 to 70.28 ± 1.076 mg·cm −2 (Fig. 7r ) in the ΔATGL male mice compared to controls.

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Interestingly, although Cpt1 , Pnpla2 and Dgat2 upregulation did not reach statistical significance in RNA sequencing analysis, it did in qRT‒PCR validation.

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