Synergistic In Vitro Antiviral Effect of Combinations of Ivermectin, Essential Oils, and 18-(Phthalimid-2-yl)ferruginol against Arboviruses and Herpesvirus.

Moreover, in a clinical study with dengue patients (DENV4/45.2%, DENV3/33.9%, DENV2/8.7%, and DENV1/7.0%), a daily oral dose of 400 μg/kg of IVM also showed a trend towards a reduction in plasma nonstructural protein 1 (NS1) clearance at day 3 compared to placebo, though clinical efficacy was not observed with that dosing regimen [ 39 ], even though in vitro, IVM EC 50 values for DENV/1-4 ranged from 1.6 to 2.3 μM in BHK-21 cells (48 hpi) [ 40 ].

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