Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases.

Here, unlike rapamycin inhibition of the mTOR pathway, colchicine recovered the relative protein expression of p-4EBP-1 in endothelial cells treated with oxidative stress for 2 h and showed a trend of its increase after 24 h (Fig. 4 A, E; Table 1 ).

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