Radiomic features define risk and are linked to DNA methylation attributes in primary CNS lymphoma.

While the transfer of the median risk score as a cutoff found in the discovery cohort did not replicate survival differences in the validation cohort, a cutoff based on the maximal hazard ratio in the discovery cohort showed a trend toward survival differences in the validation cohort ( Figure 2C , Supplementary Table S2 ; HR = 5.65 [3.53–9.04], median OS: high-risk 5.4 months, low-risk 129.6 months; Figure 2D , HR = 2.95 [1.27–6.86], median OS: high-risk 25.1 months, low-risk: not reached).

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