Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells.

In contrast to MGLs, differentiation of hiPSCs to forebrain NPCs in monoculture led to extremely low levels of IL6R expression, reduced by ∼16-fold relative to the hiPSC stage, although this failed to reach statistical significance overall ( Fig. 1 B statistics in Supplementary Table 15 ).

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