Rapamycin downregulates α-klotho in the kidneys of female rats with normal and reduced renal function

PLoS One · 2023 · PMC10684065

Europe PMC

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did not reach statistical significanceno p-value reported

Nx rats tended to increase urinary Ca excretion but the differences did not reach statistical significance.

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highly significantno p-value reported

This contention is substantiated by the correlation study which shows a highly significant inverse correlation between urine P excretion and α-klotho expression.

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