Serum β-synuclein, neurofilament light chain and glial fibrillary acidic protein as prognostic biomarkers in moderate-to-severe acute ischemic stroke.

Sci Rep · 2023 · PMC10684607 · PMID 38017278

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hedged sentences

0.0500

closest p · 1.0× alpha

0.0590

boldest claim

The sentences

of borderline significancep = 0.05actually significant

Associations between biomarker levels and post-interventional clinical and radiological variables Patients with post-interventional ASPECTS values < 8 (n = 21) showed higher serum levels of β-syn (p = 0.0014) and GFAP (p = 0.008) compared to patients with ASPECTS ≥ 8 (n = 9), whereas the increase of NfL was of borderline significance (p = 0.05) (Supplementary Fig. 2 ).

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did not reach statistical significancep = 0.059so close (0.05 < p ≤ 0.1)

Interestingly, we found significant associations between the ASPECTS values at admission and serum levels of β-syn [β: − 0.318 (95% confidence interval, 95%CI: − 0.489 to − 0.147), p = 0.0011] and GFAP [β: − 0.482 (95%CI: − 0.704to − 0.261), p = 0.0002], whereas the association with NfL did not reach statistical significance [β: − 0.149 (95%CI − 0.297 to − 0.0008), p = 0.059].

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