NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson's disease.

Nat Commun · 2023 · PMC10684646 · PMID 38016950

Europe PMC DOI

hedged sentences

0.0570

closest p · 1.1× alpha

0.0570

boldest claim

The sentences

a strong trendp = 0.057so close (0.05 < p ≤ 0.1)

The mean of the individual changes (Δ = V7–V1) in each of these metabolites was also significantly different between the NR and placebo groups, with the exception of NADP + , which, however, showed a strong trend after multiple testing correction ( p = 0.057; Supplementary Data 6 ).

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a mild trendno p-value reported

This was, in turn, associated with altered cerebral metabolism and a mild trend for clinical improvement 18 .

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