The only prospective randomized study on the prophylactic use of medication to prevent transmission from week 14 + 0 of gestation compared spiramycin with primethamine/sulfadiazine and found a tendency to lower rates of transmission with pyrimethamine/sulfadiazine (did not reach statistical significance, Fig. 6 ).
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Toxoplasma gondii Infection in Pregnancy - Recommendations of the Working Group on Obstetrics and Prenatal Medicine (AGG - Section on Maternal Disorders).
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