Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity.

The average power of γ-oscillatory activity was significantly reduced in brain-specific conditional N4-1/N4-2 KO mice ( Nedd4-1 f/f ; Nedd4-2 f/f ; EMX -Cre; N4-1/2 bDKO; Gorski et al., 2002 ; Kawabe et al., 2010 ; Kimura et al., 2011 ) or showed a strong trend toward a significant reduction (P = 0.076) in brain-specific N4-2 KO mice ( Nedd4-2 f/f ; EMX -Cre; N4-2 bKO) as compared with their corresponding controls ( Nedd4-1 f/f ; Nedd4-2 f/f ; N4-1/2 CTL and Nedd4-2 f/f ; N4-2 CTL, respectively) when tested with a stringent statistical test (i.e., nested t test; Fig. 1 ).

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