NTHL1 is a recessive cancer susceptibility gene.

We detected two variants, MAD1L1 NM_001013836.2 :c.1947C>G p.(Tyr649Ter) and USP45 NM_001346022.3 :c.2190C>A p.(Tyr730Ter), with a higher frequency in the patients than in the controls on a nominally significant level (P < 0.05) (Table 1 ); however, another pLoF in the USP45 gene, NM_001346022.3 :c.1008del p.(Val337SerfsTer9), was found only slightly more often in the patients than in the controls.

also in 7,732 other papers