Sex and gonadectomy modify behavioral seizure susceptibility and mortality in a repeated low-dose kainic acid systemic injection paradigm in mice.

Epilepsia Open · 2023 · PMC10690657 · PMID 37715318

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a trend approaching significanceP = 0.069so close (0.05 < p ≤ 0.1)

Although no two groups differed significantly in the rate of SE induction within two injections by pairwise testing, a larger proportion of ORX males (n = 8 of 9) reached SE by three injections compared to both control males (n = 2 of 14; P = 0.004) and control females (n = 2 of 13; P = 0.009), with a trend approaching significance in comparison to OVX females (n = 11 of 18; P = 0.069).

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