Peripheral T cell activation, not thymic selection, expands the T follicular helper repertoire in a lupus-prone murine model.

The small number of TCR α:β clonotypes obtained in this experiment restricts the ability to discern physiologically relevant differences in repertoire diversity between the two groups ( 23 ); nonetheless, we did note that the Shannon diversity was increased in cells stimulated with BLIMP1-deficient DCs compared to control DCs, although the difference did not reach statistical significance ( Fig. 7 F ).

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