Barely Significant
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Preliminary evidence that ketamine alters anterior cingulate resting-state functional connectivity in depressed individuals.

Transl Psychiatry · 2023 · PMC10692230 · PMID 38040678

1
hedged sentence
0.0570
closest p · 1.1× alpha
0.0570
boldest claim

The sentences

showed a trendp = 0.057so close (0.05 < p ≤ 0.1)
Clinical results At day two following treatment, ketamine significantly improved MADRS scores (mean difference -6.5 [95% CI -10.6 to -2.5]; paired t -test, p = 0.003), TEPS-anticipatory scores (mean difference 6.8 [95% CI 2.9 to 9.5]; paired t -test, p = 0.038), TEPS-consummatory scores (mean difference 5.6 [95% CI 1.8 to 6.1]; paired t -test, p = 0.018) and showed a trend to improve SHAPS scores (mean difference -5.2 [95% CI -10.7 to 0.2]; paired t -test, p = 0.057) compared to placebo (Supplementary Fig.

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