Immuno-inflammatory <i>in vitro</i> hepatotoxicity models to assess side effects of biologicals exemplified by aldesleukin.

Front Immunol · 2023 · PMC10693457 · PMID 38045689

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did not reach statistical significanceno p-value reported

In the direct CD8 + T cell/HepaRG co-culture, concentrations of the cytolytic molecule perforin were increased 8.4-fold by 5000 IU/mL aldesleukin compared to the vehicle control, but the increase did not reach statistical significance ( Figure 4F ).

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