Cellular viability was significantly reduced also in MCF7 blue TAMR_1 and red LTED_5 clones upon treatment with 2.50 μM Sotrastaurin and showed a trend when compared to Sotrastaurin-treated +E2_5 control cells (Fig. 6c ).
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Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets.
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