Extreme deviations from the normative model reveal cortical heterogeneity and associations with negative symptom severity in first-episode psychosis from the OPTiMiSE and GAP studies.

Also, although highly significant, the effects that we report are of moderate magnitude and we consider that validation in prospective data is an important next step to assess the generalisability and clinical value of our findings.

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Twenty-three regions also demonstrated a nominally significant relationship with remission status, but these findings did not remain significant after correction for multiple comparisons.

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