Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes.

Here, compared with placebo, we observed absolute decreases in average urinary putrescine, the direct product of ODC ( Figure 1 A), with DFMO treatment for all treatment groups, with significant or near-significant differences in the 500 (p = 0.03) and 1,000 mg/m 2 (p = 0.05) dosing groups.

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