Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1.

Although there was a trend toward increased anti-tumor efficacy at the late time point with combined LSN3321213 and PD-L1 compared to LSN3321213 alone, the data did not reach statistical significance (p = 0.07, relative risk [RR] = 0.32, 95% CI [0.09, 0.94]) ( Table S1 D).

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Tumors treated with combined LSN3321213 and PD-L1 or LSN3321213 alone had a significant increase in intra-tumoral CD4 + T cells and a trend toward significance of intra-tumoral CD8 + T cells ( Figures 4 E and S7 D).

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