Composition and diversity analysis of the TCR CDR3 repertoire in patients with idiopathic orbital inflammation using high-throughput sequencing.

BMC Ophthalmol · 2023 · PMC10694961 · PMID 38044453

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0.0650

closest p · 1.3× alpha

0.0650

boldest claim

The sentences

showed a trendP = 0.065so close (0.05 < p ≤ 0.1)

At the TRBV20-1 and TRBV29-1 sequences, the frequency of use showed a trend of difference that was not significant between the IOI and the HC groups (P = 0.065, P = 0.065) (Fig. 3 A).

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a nonsignificant trendno p-value reported

In the six patients for whom blood samples before and after glucocorticoid treatment were available, there was a nonsignificant trend toward higher diversity, suggesting that the diversity of TCRs in patients with IOI may have been restored to some extent after glucocorticoid treatment, which is consistent with the results reported in the literature above.

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