Molecular bases for strong phenotypic effects of single synonymous codon substitutions in the E. coli ccdB toxin gene.

BMC Genomics · 2023 · PMC10694988 · PMID 38049728

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a clear trendno p-value reported

The data showed a clear trend, i.e., ES CcdB increased with increased RCU for N-terminal residues, indicating mutations to more frequently used codons decreased CcdB levels in the cell.

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an overall trendno p-value reported

We observed an overall trend wherein occlusion of the RBS was associated with a higher value of ES CcdB .

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