Cholic acid increases plasma cholesterol in Smith-Lemli-Opitz syndrome: A pilot study.

Mol Genet Metab Rep · 2024 · PMC10698565 · PMID 38077958

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

7-Ketocholesterol trended lower but did not reach statistical significance ( p = 0.06).

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a decreasing trendp = 0.06so close (0.05 < p ≤ 0.1)

Furthermore, 7 keto-cholesterol, which can be formed from cholesterol via autoxidation [ 28 ] or from 7-DHC via CYP7A1 [ 29 , 30 ], showed a decreasing trend with cholic acid treatment, particularly for patients with a high baseline level ( p = 0.06).

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