Pharmacological NF-κB inhibition decreases cisplatin chemoresistance in muscle-invasive bladder cancer and reduces cisplatin-induced toxicities.

However, when the analyses were restricted to the 115 patients who subsequently received chemotherapy (adjuvant or salvage) using multiple gene sets representing the NF‐κB pathway, we observed a highly significant association ( P = 0.00076) with disease‐specific survival as well as a significant association ( P = 0.017) with overall survival (Fig. 1J,K ).

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The cisplatin plus DMAPT combination caused more DNA damage than cisplatin alone, although the difference between the two groups did not reach statistical significance ( P = 0.053; Fig. 2L–O ).

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