Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis.

Nat Genet · 2023 · PMC10703693 · PMID 37932435

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0000

boldest claim

The sentences

highly significantP = 5.64 × 10 −10actually significant

While TET2 -CH, for example, showed a highly significant slope when regressed on barcode-CH ( m = 0.94, P = 5.64 × 10 −10 ), the slope for ASXL1 -CH versus barcode-CH was much shallower and of lower significance ( m = 0.41, P = 8.76 × 10 −4 ).

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nominally significantno p-value reported

Unadjusted for smoking, no CVD phenotype passed Bonferroni significance and, once adjusted, none was even nominally significant.

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