Changes in Treg and Breg cells in a healthy pediatric population.

Interestingly, activated eTreg (CD4 + CD25 hi CD127 low CD45RO + CCR4 + HLA-DR + ) showed an increasing trend from 3 to 7 years, were more marked in the 5–7-year range (median 22.8% at 1-3 years vs 34.4% at 5-7 years; p = 0.012), and the frequency decreased thereafter ( Supplementary Figure 4G ).

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Interestingly, we observed a tendency for CD4 + CD25 hi FoxP3 + to increase from 3 to 7 years compared to the youngest (1-3 years) (median 0.9% at 1-3 years vs 1.77% at 5-7 years; p = 0.045), although it did not reach statistical significance at 3-5 years.

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