Preoperative Intensified Chemoradiation with Intensity-Modulated Radiotherapy and Simultaneous Integrated Boost Combined with Capecitabine in Locally Advanced Rectal Cancer: Long-Term Outcomes of a Real-Life Multicenter Study.

Cancers (Basel) · 2023 · PMC10705284 · PMID 38067405

Europe PMC DOI

hedged sentences

0.0550

closest p · 1.1× alpha

0.0620

boldest claim

The sentences

an unfavorable trendp = 0.055so close (0.05 < p ≤ 0.1)

The administration of adjuvant chemotherapy was associated with worse PFS ( p = 0.013), and an unfavorable trend was also observed for DM incidence ( p = 0.055).

also in 30 other papers

a favorable trendp = 0.056so close (0.05 < p ≤ 0.1)

A favorable trend for better response was found for a higher IMRT-SIB dose ≥ 55 Gy (OR 0.57; 0.32–1.01, p = 0.056).

also in 313 other papers

marginally significantp = 0.062so close (0.05 < p ≤ 0.1)

In particular, the DM rate was higher, marginally significant, in the high-risk sub-set of patients reaching a 24.5% compared to 16.2% of low and intermediate risk ( p = 0.062).

also in 5,089 other papers

a positive trendno p-value reported

Multivariable analysis found no significant impact on tumor response (pCR, TRG1-2) or downstaging for the different dose levels, although a positive trend was observed for doses ≥ 55 Gy.

also in 3,084 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.