The Fundamental Role of Oxime and Oxime Ether Moieties in Improving the Physicochemical and Anticancer Properties of Structurally Diverse Scaffolds.

Int J Mol Sci · 2023 · PMC10705934 · PMID 38069175

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quite significantno p-value reported

The difference in activity between the N -unsubstituted 72 and the N -methyl substituted derivative 74 was quite significant, underscoring the potential importance of a free amine interaction within the binding pocket through hydrogen bonds [ 120 ].

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