While the median IL-6 and IL-8 production was higher in presence of cell culture supernatant from IL-17A+ CD8+ MAIT cells compared with conventional T-cells (median: 63 700 pg/ml versus 29 500 pg/ml and 1500 pg/ml versus 280 pg/ml, respectively), this difference did not reach statistical significance ( Fig. 6B ).
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Human in vitro-induced IL-17A+ CD8+ T-cells exert pro-inflammatory effects on synovial fibroblasts.
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