Germline ablation achieved via CRISPR/Cas9 targeting of <i>NANOS3</i> in bovine zygotes.

On average, the NANOS3 KO fetal and perinatal testis pairs weighed less than age-matched control testis pairs, although this difference did not reach statistical significance ( Figures 2B, C ). 3.4.1 Germline ablation observed by 41 days in CRISPR/Cas9 NANOS3 KO bovine fetal gonads In this study, NANOS3 targeted, and control fetuses were first collected at 41 days, corresponding to the stage of sexual differentiation, which is approximately 2 weeks after PGCs would first be expected to reach the genital ridge and two-three days after peak SRY expression.

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