Direct Oral Anticoagulant Dosing in Patients With Atrial Fibrillation: An Asian Perspective.

The risks of stroke/SE and major bleeding were not significantly different based on the level of dosing, although underdosed patients had a significantly lower risk of bleeding and overdosed patients showed a trend toward higher risks of stroke/SE and major bleeding, although not statistically significant. 41 A few other studies have shown that among DOACs, underdosing of apixaban was associated with a higher risk of stroke 42 , 45 or all-cause mortality. 46 An analysis of the ENGAGE AF-TIMI 48 trial showed that the risk of stroke/SE was higher, but the risk of major bleeding was lower with the lower-dose edoxaban regimen (LDER) compared with the higher-dose edoxaban regimen (HDER).

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