There was a strong trend for an increase in CD4 + thymocytes in the SLE mice that received the leptin antagonist ( Figure 4 G), so it may be that positive selection of DP thymocytes into a CD4 + or CD8 + thymocytes is impacted in some way.
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Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease.
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