Effect of statin treatment on metabolites, lipids and prostanoids in patients with Statin Associated Muscle Symptoms (SAMS).

PLoS One · 2023 · PMC10723679 · PMID 38100464

Europe PMC DOI

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closest p · 1.0× alpha

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boldest claim

The sentences

nominally significantp≤0.05actually significant

Metabolomic analyses Positive ion metabolites that were identified as nominally significant (p≤0.05) in SAMS patients are shown in S5 Table of S3 File .

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may be significantno p-value reported

Significance of observed differences in specific lipids and metabolites Phospholipids Insofar as linoleic acid (18.2) can be converted to longer-chain fatty acids including the pro-inflammatory eicosanoid arachidonic acid (20:4) [ 36 ], the observed increase in phospholipids containing linoleic acid tails in plasma of SAMS patients may be significant.

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