Longitudinal microbial and molecular dynamics in the cystic fibrosis lung after Elexacaftor-Tezacaftor-Ivacaftor therapy.

These log-ratios revealed a positive relationship with time on ETI in 4/7 subjects with one reaching statistical significance of the linear regression at an alpha-level of 0.05 and two others nearing significance (p = 0.052 and p = 0.056; Fig. 4 B).

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Modeling the immigration rate over time predicted a negative trend, possibly reflecting the re-establishment of a new configuration, but further work is needed to determine if the microbiome and metabolome of CF airways have reached a new steady state with the broad administration of ETI.

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