Vulnerable and Stabilized States After Cerebral Ischemic Events: Implications of Kinetic Modeling in the SOCRATES, POINT, and THALES Trials.

By contrast, there were significant or near-significant decreases in the value of k 1 in active treatment vs control groups in each trial, and a significant decrease in the average k 1 across the trials ( Table 3 ; control k 1 = 0.030 ± 0.004 vs active treatment k 1 = 0.016 ± 0.003, p < 0.01).

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It is intriguing that in SOCRATES, although the overall effect of treatment on the primary trial end point did not achieve significance, the present analysis suggests that treatment assignment to the rapidly acting antiplatelet agent ticagrelor had a potentially significant effect only in the subset of subjects randomized within 12 hours of the index stroke or TIA, supporting an effect of the active treatment when administered quickly, within 12 hours from the index event.

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