Evolution of HIV-1 envelope towards reduced neutralization sensitivity, as demonstrated by contemporary HIV-1 subtype B from the United States.

NAbs targeting the V3, CD4bs, and MPER demonstrated a significant trend in increasing order of median IC 50 s (p = 0.0001, 0.0135, and 0.0249, respectively) and decreasing order of median breadth (p = 0.0001, 0.0598, and 0.0098, respectively) over time.

also in 1,007 other papers

To ensure concordance between data generated in our MHRP laboratory and previously published CATNAP data, we performed a bridging analysis using 3 PSVs and 18 NAbs and observed a highly significant correlation between IC 50 endpoints ( S2 Fig , p<0.0001, r = 0.9043).

also in 11,749 other papers