Effectiveness of intraoral splints in the treatment of migraine and tension-type headache: A systematic review.

Although some of the studies (Goncalves et al., 2013 ) did observe a greater improvement in frequency, pain intensity, and disability when combining propranolol with intraoral splints relative to other groups (propranolol monotherapy, intraoral splints monotherapy, and placebo), the difference between groups on these outcomes did not reach statistical significance and clinical relevance.

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