A Critical Assessment of Diagnostic Criteria for the Tall Cell Subtype of Papillary Thyroid Carcinoma-How Much? How Tall? And When Is It Relevant?

However, in the subset of tumours otherwise similar to the American Thyroid Association (ATA) guidelines low-risk category, WHO TC-PTC demonstrated a highly significant reduction in DFS ( p = 0.004).

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However, on subgroup analysis when tumours were separated into otherwise low-risk or high-risk PTCs, the presence of TC-PTC by three criteria (2 × and 50%, 3 × and 30%, and 3 × and 50%) was statistically significant in low-risk patients ( p = 0.049, p = 0.004, and p = 0.004, respectively) and the criteria of 2 × and 30% just failed to reach statistical significance ( p = 0.063).

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However, when TC-PTC was defined as cells 3 times as tall as wide in 30% of more the tumour (the WHO 2022 criteria), TC-PTC failed to reach statistical significance ( p = 0.122).

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