For all secondary endpoints in the double-blind period, the ESC group showed a trend toward improvement compared with the placebo group at week 48, and four of six endpoints, including change from start of the double-blind period in CDRS-R total score, were statistically significantly different between the two groups.
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Efficacy of Preventing Relapse Evaluated by a Multicenter Randomized Double-Blind Placebo-Controlled Withdrawal Study of Escitalopram in Japanese Adolescents with Major Depressive Disorder.
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