Rapid Metabolic Profiling of 1 μL Crude Cerebrospinal Fluid by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Can Differentiate <i>De Novo</i> Parkinson's Disease.

Limits of detection were estimated for multiple neurotransmitters with high linearity ( R 2 > 0.99) and sensitivity (as low as 16 pg/μL). Application of multivariate classification led to a highly significant ( P < 0.001) model of PD prediction with a 100% classification rate, which was further thoroughly validated with a permutation test and univariate analysis.

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Eleven m / z values ( Table S4 ) were found to be of statistical significance ( P < 0.05, FDR < 0.1), while hypoxanthine (double-derivatized, m / z 657.240) demonstrated a strong trend ( P = 0.093).

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