Indeed, while the precocious reduction of neutrophil counts during CDK4/6i therapy showed a trend toward an association with better patient PFS, CDK4/6i-induced reduction of monocyte and platelet counts was even associated with a trend toward worse PFS ( Supplemental Figure 5–7 ).
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Peripheral blood lymphocytes predict clinical outcomes in hormone receptor-positive HER2-negative advanced breast cancer patients treated with CDK4/6 inhibitors.
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