Evaluation of the osteogenic potential of demineralized and decellularized bovine bone granules following implantation in rat calvaria critical-size defect model.

PLoS One · 2023 · PMC10734957 · PMID 38127838

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showed a trendno p-value reported

Micro-CT analysis further showed a trend of lower bone density at DMB implanted sites compared to DCC, however, the observed difference was not statistically significant ( Fig 6e ).

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highly significantno p-value reported

The RAMAN spectroscopy analysis revealed a highly significant increase in phosphate levels by day 60 in defects implanted with DCC bone granules supporting the increased new bone formation observed by histomorphometry.

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