Among erasers, FTO and ALKBH5 also showed a trend in expression of first increasing and then decreasing, peaking at 5 weeks (Fig. 1c ).
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FTO-mediated m<sup>6</sup>A demethylation regulates GnRH expression in the hypothalamus via the PLCβ3/Ca<sup>2+</sup>/CAMK signalling pathway.
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Among readers, FMR1 , YTHDC1/2 , and YTHDF2 showed an increasing trend in expression, while RBMX and YTHDF1/3 showed no significant differences.
m 6 A expression showed a decreasing trend during pubertal development.