SLC16a6, mTORC1, and Autophagy Regulate Ketone Body Excretion in the Intestinal Cells.

We also found that the knockdown of beclin1, a key molecule in the autophagic machinery, partially reduced extracellular ketone body concentration in the starvation-mimicked medium with the accumulation of autophagy substrate p62 and a reduction in LC3 but did not reach statistical significance ( Figure 3 C,E and Supplementary Materials, Figure S3B–E ).

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