Secreted Protein Acidic and Rich in Cysteine (<i>SPARC)</i> Polymorphisms in Response to Neoadjuvant Chemotherapy in HER2-Negative Breast Cancer Patients.

Biomedicines · 2023 · PMC10741005 · PMID 38137452

Europe PMC DOI

hedged sentences

0.0690

closest p · 1.4× alpha

0.0890

boldest claim

The sentences

showed a trendp = 0.069so close (0.05 < p ≤ 0.1)

However, the rs19789707 variant showed a trend towards significance ( p = 0.069); the 5-year OS was 100% (95% CI, not applicable (NA)) in heterozygous patients compared to 95% (95% CI, 81.9–98.8%) in the AA genotype patients and 91% (95% CI, 68.8–97.7%) in the GG genotype patients. 3.5.

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a trend towards significancep = 0.089so close (0.05 < p ≤ 0.1)

For the rs19789707 variant, we observed a trend towards significance; the 5-year EFS was 84% (95% CI, 57.1–94.8) in patients with the GG genotype and 94% (95% CI, 87.4–97.3%) in patients carrying the A allele ( p = 0.089 in a recessive model).

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