While the increase in TDP-43 aggregates due to CHCHD10 knockdown in the soluble fraction did not reach statistical significance ( Figure 7 a,c), CHCHD10 knockdown increased TDP-43 aggregates by a significant four-fold in the insoluble fraction ( Figure 7 a,c).
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Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion.
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